This was the article I decided to pick to present and focused on atopic dermatitis. This diseases is common and chronic characterized by pruritus and eczema, often linked to hypersensitivity reactions, especially in individuals with allergic conditions like allergic rhinitis and asthma. The pathophysiology of AD is primarily due to an impaired epidermal barrier and immune dysregulation. Traditional treatments, including antihistamines and immune modulatory agents like corticosteroids and calcineurin inhibitors, focus on reducing inflammation but can be limited by side effects and low patient adherence. This high-quality systematic review and meta-analysis has highlighted the association between low vitamin D levels and AD, particularly in pediatric cases, and evaluated the potential benefits of vitamin D supplementation. Serum 25(OH)D levels were found to be lower in AD patients compared to controls, with a more pronounced deficiency in children. Studies that included pediatric patients aged 7–14 administered 1,000 to 1,600 IU of vitamin D3 daily for 1-2 months, showing promising results. While vitamin D supplementation appears beneficial for AD patients, especially those with low vitamin D levels, caution is warranted due to potential risks; high doses during early life have been associated with an increased risk of food allergies. Further large-scale studies are needed to better understand the mechanisms of vitamin D in AD and to confirm its effectiveness in AD management.